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KMID : 0613820060160030442
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Journal of Life Science
2006 Volume.16 No. 3 p.442 ~ p.446
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Inhibition of Matrix Metalloproteinase-2 Activity of Flavonol Glycosides from Cedrela sinensis
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Hwang Seon-Woo
Ha Tae-Joung
Kho Yung-Hee
Chun Hyo-Kon
Lee Jun
Kwon Hyun-Sook
Park Ki-Hoon
Yang Min-Suk
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Abstract
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Cedrela sinensis is a broadleaf tree that is widely cultivated in Korea and China. It was used for treating enteritis, dysentery, and skin itch in oriental medicine. In this study, three major flavonoids, kaempferol-3-O-rhamnoside (1), quercetin-3-O-rhamnoside (2), and quercetin-3-O-glucoside (3), were isolated from the leaf of Cedrela sinensis. The biological activities of these compounds were tested by inhibitory activity of matrix metalloproteinases-2 (Type IV collagenase) method together with a cytotoxicity and a apoptosis test against human cancer cell lines.
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KEYWORD
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Cedrela sinensis, flavonol glycosides, cytotoxic activity, apoptosis, matrix metalloproteinases-2
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